Claudin 6/9 antibody

Catalog No. ABIN1720918

This Rat Monoclonal antibody specifically detects in cELISA and FACS. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for Claudin 6/9 antibody (ABIN1720918)

Target: Claudin 6/9

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Application: Cell-ELISA (cELISA), Flow Cytometry (FACS)

Clone: YD-9H8

Product Details

Specificity: Anti-human Claudin 6 and Claudin 9

Characteristics: Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells

Purification: Protein G

Immunogen: genetic immunisation with cDNA encoding human Claudin 9

Isotype: IgG2b

Application Details

Application Notes: Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Comment:

Synonyms: CLDN6, CLDN9

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C

Storage Comment: short term: 2 °C - 8 °C, long term: -20 °C

References

Fofana, Zona, Thumann, Heydmann, Durand, Lupberger, Blum, Pessaux, Gondeau, Reynolds, McKeating, Grunert, Thompson, Zeisel, Baumert: "Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies." in: Journal of virology, Vol. 87, Issue 18, pp. 10405-10, (2013) (PubMed).

Target Details

Target: Claudin 6/9

Background: Claudin 6 and 9 play a major role in tight junction-specific obliteration of the intercellular space. Claudin 6 and Claudin 9 have been reported to mediate HCV entry

UniProt: P19235, O95484